Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826282 | 0.85 | TGM2 (0.43) | TGM2ITGB3ITGA2BOPRD1CTSL | |
| SCHEMBL4934993 | 0.82 | TGM2 (0.49) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL4934061 | 0.82 | TGM2 (0.49) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL9825095 | 0.82 | TGM2 (0.37) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL9826384 | 0.82 | TGM2 (0.37) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL4936405 | 0.81 | TGM2 (0.38) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL9825346 | 0.81 | TGM2 (0.38) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL9825676 | 0.80 | TGM2 (0.47) | TGM2ITGB3ITGA2BSLC7A5TYR | |
| SCHEMBL9825692 | 0.80 | TGM2 (0.46) | TGM2 | |
| SCHEMBL4950332 | 0.79 | TGM2 (0.47) | TGM2ITGB3ITGA2BSLC7A5TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |