Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 17/20 | 0.67 |
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827681 | 1.00 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6966141 | 0.92 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6966138 | 0.92 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9828739 | 0.89 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9828157 | 0.89 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL30383726 | 0.89 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6967961 | 0.87 | CYSLTR2 (0.85) | CYSLTR1CYSLTR2 | |
| SCHEMBL6967958 | 0.87 | CYSLTR2 (0.85) | CYSLTR1CYSLTR2 | |
| SCHEMBL6954787 | 0.84 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6954791 | 0.84 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |