SCHEMBL9828002

SCHEMBL9828002

COc1ccc2cnccc2c1OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.53
TDO2 P48775 7/20 0.45
IDO1 P14902 6/20 0.45
CYP3A4 P08684 2/20 0.44
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 3/20 0.43
NSD2 O96028 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
BRAF P15056 1/20 0.42
CHUK O15111 1/20 0.42
PRKD3 O94806 1/20 0.42
PRKCG P05129 1/20 0.42
PRKCB P05771 1/20 0.42
PRKCA P17252 1/20 0.42
CSNK2A2 P19784 1/20 0.42
PRKCH P24723 1/20 0.42
PRKCI P41743 1/20 0.42
CSNK2B P67870 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7865819 0.85 MAOA (0.67) MAOATDO2IDO1CYP3A4KDM4E
SCHEMBL18318161 0.81 MAOA (0.45) MAOACYP3A4KDM4EALDH1A1NSD2
SCHEMBL25607551 0.80 MAOA (0.47) MAOACYP3A4KDM4EALDH1A1NSD2
SCHEMBL2384131 0.80 CYP19A1 (0.58) MAOACYP3A4KDM4EALDH1A1NSD2
SCHEMBL9826468 0.80 MAOA (0.75) MAOACYP3A4BRAF
SCHEMBL4813555 0.80 CYP11B1 (0.58) MAOATDO2IDO1CYP3A4KDM4E
SCHEMBL8396416 0.80 HASPIN (0.50) MAOACYP3A4KDM4EALDH1A1NSD2
SCHEMBL27323785 0.79 MAOA (0.44) MAOACYP3A4KDM4EALDH1A1NSD2
SCHEMBL28013610 0.78 MAOA (0.47) MAOACYP3A4KDM4EALDH1A1NSD2
Hydrochloric Acid SCHEMBL27344700 0.78 MAOA (0.46) MAOACYP3A4KDM4EALDH1A1NSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0182210-A2 Cephalosporin derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1986-05-28 EP claimed
EP-0182210-B1 CEPHALOSPORIN DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1991-02-27 EP disclosed
US-4742053-A ANTIBIOTICS BANYU PHARMACEUTICAL CO., LTD. (JP) 1988-05-03 US disclosed
EP-0182210-A2 Cephalosporin derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1986-05-28 EP disclosed