Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17450949 | 0.85 | CA2 (0.42) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL2433684 | 0.84 | POLB (0.43) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL30103969 | 0.81 | POLB (0.50) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL31414692 | 0.79 | TAAR1 (0.53) | POLBL3MBTL1MAPTNPSR1HTR2A | |
| SCHEMBL26611762 | 0.79 | TAAR1 (0.53) | POLBL3MBTL1MAPTNPSR1HTR2A | |
| SCHEMBL19407727 | 0.78 | POLB (0.38) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL2435681 | 0.77 | USP8 (0.41) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL19240443 | 0.76 | NQO2 (0.40) | POLBL3MBTL1MAPTNPSR1NQO2 | |
| SCHEMBL31214365 | 0.76 | MEN1 (0.34) | POLBMAPTNPSR1AMY1AALDH1A1 | |
| SCHEMBL19364026 | 0.75 | POLB (0.36) | POLBL3MBTL1MAPTNPSR1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199324-B1 | NEW 2,5-DIARYL TETRYHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0199324-A2 | New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |