Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032817 | 0.86 | GPBAR1 (0.52) | GPBAR1CYSLTR1HDAC1HDAC2CYSLTR2 | |
| SCHEMBL9032810 | 0.86 | GPBAR1 (0.52) | GPBAR1CYSLTR1HDAC1HDAC2CYSLTR2 | |
| SCHEMBL7009315 | 0.86 | GPBAR1 (0.69) | GPBAR1CYSLTR1FFAR1AKR1B1CYSLTR2 | |
| SCHEMBL3271805 | 0.85 | GPBAR1 (0.62) | GPBAR1CYSLTR1FFAR1AKR1B1HDAC1 | |
| SCHEMBL10546745 | 0.79 | CYSLTR2 (0.50) | CYSLTR1CYP1A2CYP2C9CYP2C19CYSLTR2 | |
| SCHEMBL11189080 | 0.78 | RXFP1 (0.60) | GPBAR1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9023173 | 0.77 | CYSLTR1 (0.69) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL7456253 | 0.77 | CYSLTR1 (0.49) | GPBAR1CYSLTR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9828136 | 0.77 | TSHR (0.55) | GPBAR1CYSLTR1FFAR1AKR1B1HDAC1 | |
| SCHEMBL9829523 | 0.76 | GPBAR1 (0.51) | GPBAR1CYSLTR1FFAR1AKR1B1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |