Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457596 | 0.89 | HSD17B10 (0.54) | HSD17B10ALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL8022232 | 0.83 | ALDH1A1 (0.49) | HSD17B10ALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL4542517 | 0.82 | ALDH1A1 (0.63) | HSD17B10ALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL29111421 | 0.82 | ALDH1A1 (0.65) | HSD17B10ALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL2680807 | 0.82 | ALDH1A1 (0.45) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL2335896 | 0.81 | ALDH1A1 (0.50) | HSD17B10ALDH1A1MAPTCYP1A2TDP1 | |
| SCHEMBL30426642 | 0.81 | ALDH1A1 (0.50) | HSD17B10ALDH1A1MAPTCYP1A2TDP1 | |
| SCHEMBL8110374 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL7122419 | 0.81 | TUBB1 (0.49) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL30287280 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199324-B1 | NEW 2,5-DIARYL TETRYHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5010100-A | Skeletal muscular disorders, hydertensive agents, cardiovascular disorders | MERCK & CO. INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0199324-A2 | New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |