Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12024479 | 0.88 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL10806203 | 0.87 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL8541406 | 0.86 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL12024482 | 0.84 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL3042081 | 0.82 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL12024477 | 0.82 | ABCB1 (0.61) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL28250051 | 0.81 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL28456891 | 0.81 | MAPT (0.58) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6301076 | 0.81 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TSHRNPSR1 | |
| SCHEMBL9828913 | 0.80 | SMN1; SMN2 (0.60) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |