Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.46 |
| ▸ | LOX | P28300 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830450 | 0.84 | CA2 (0.65) | CA2LOXCA1ALDH1A1CA9 | |
| SCHEMBL9828579 | 0.79 | CA2 (0.54) | CA2LOXCA1HSD17B10 | |
| SCHEMBL9830576 | 0.79 | CA2 (0.46) | CA2LOXCA1CA9 | |
| SCHEMBL9828530 | 0.78 | CA2 (0.50) | CA2LOXCA1ALDH1A1TSHR | |
| SCHEMBL9830808 | 0.77 | CA2 (0.47) | CA2LOXCA1ALDH1A1CA9 | |
| SCHEMBL9829011 | 0.76 | LOX (0.52) | CA2LOXCA1CA9 | |
| SCHEMBL10589348 | 0.76 | CA2 (0.59) | CA2LOXCA1CA9 | |
| SCHEMBL9830538 | 0.75 | CA2 (0.49) | CA2LOXCA1CA9 | |
| SCHEMBL9827924 | 0.74 | CA2 (0.58) | CA2LOXCA1CA9 | |
| SCHEMBL9828357 | 0.74 | CA2 (0.54) | CA2LOXCA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |