Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.35 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19480055 | 0.89 | EPHX2 (0.49) | ALOX15 | |
| SCHEMBL5426320 | 0.83 | EPHX1 (0.44) | EPHX1NAAACASP2ZDHHC20ZDHHC2 | |
| SCHEMBL31477734 | 0.80 | ALOX15 (0.42) | EPHX1SMN1; SMN2AKR1B1ALOX15KDM4C | |
| SCHEMBL29382795 | 0.79 | NAALAD2 (0.51) | AKR1B1ALOX15PLA2G2AALDH1A1TSHR | |
| SCHEMBL3885213 | 0.78 | KDM4C (0.47) | EPHX1NAAACASP2AKR1B1ALOX15 | |
| SCHEMBL23052825 | 0.78 | MEN1 (0.36) | ALOX15ALDH1A1TSHR | |
| SCHEMBL20999124 | 0.77 | TSHR (0.39) | KDM4CALDH1A1TSHR | |
| SCHEMBL22487748 | 0.77 | TSHR (0.39) | KDM4CALDH1A1TSHR | |
| SCHEMBL10207220 | 0.77 | TSHR (0.39) | KDM4CALDH1A1TSHR | |
| SCHEMBL23177887 | 0.76 | MEN1 (0.35) | ALOX15ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |