Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829642 | 1.00 | POLB (0.50) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9830746 | 0.88 | NPC1 (0.44) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9830749 | 0.88 | NPC1 (0.44) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12471403 | 0.83 | POLB (0.54) | POLBNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL15524616 | 0.81 | NAALAD2 (0.59) | POLBNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL2789685 | 0.81 | HCAR2 (0.36) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL17825491 | 0.80 | POLB (0.51) | POLBNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL22832249 | 0.80 | POLB (0.51) | POLBNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL9828829 | 0.79 | POLB (0.57) | POLBNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL28456818 | 0.79 | POLB (0.57) | POLBNPC1RAB9ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |