Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 5/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830749 | 1.00 | NPC1 (0.44) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL9829639 | 0.88 | POLB (0.50) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL9829642 | 0.88 | POLB (0.50) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL2789685 | 0.79 | HCAR2 (0.36) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL28919652 | 0.73 | BLM (0.48) | HPGDSMN1; SMN2MAPK1CYP3A4BLM | |
| SCHEMBL5580940 | 0.72 | BLM (0.50) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL5580942 | 0.72 | BLM (0.50) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL24534558 | 0.72 | HDAC1 (0.50) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL12471403 | 0.71 | POLB (0.54) | NPC1RAB9ASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL162828 | 0.70 | TSHR (0.54) | SMN1; SMN2CYP3A4BLMMPOKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |