Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379887 | 0.86 | GAA (0.55) | KDM4ETDP1MEN1ALDH1A1TSHR | |
| SCHEMBL25854573 | 0.84 | KDM4E (0.60) | KDM4ETDP1LMNAPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL27837634 | 0.82 | KDM4E (0.63) | KDM4ETDP1LMNAHTTPOLB | |
| SCHEMBL6604508 | 0.81 | KDM4E (0.80) | KDM4ETDP1MEN1ALDH1A1TSHR | |
| SCHEMBL1427564 | 0.80 | KDM4E (0.83) | KDM4ETDP1MEN1ALDH1A1TSHR | |
| SCHEMBL9831262 | 0.79 | KDM4E (0.64) | KDM4ETDP1LMNAPOLBMEN1 | |
| SCHEMBL2760407 | 0.79 | MEN1 (0.62) | KDM4ETDP1POLBMEN1ALDH1A1 | |
| SCHEMBL9830022 | 0.79 | KDM4E (0.68) | KDM4ETDP1POLBMEN1ALDH1A1 | |
| SCHEMBL12879726 | 0.79 | KDM4E (0.68) | KDM4ETDP1POLBMEN1ALDH1A1 | |
| SCHEMBL24746190 | 0.79 | KDM4E (0.55) | KDM4ETDP1MEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |