Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL986300 | 0.95 | CDK9 (0.39) | CDK9CCNT1OPRL1KMT2AMEN1 | |
| SCHEMBL985719 | 0.92 | EPHX2 (0.40) | BRD4CDK9CCNT1KMT2AMEN1 | |
| SCHEMBL986177 | 0.92 | CCNT1 (0.40) | BRD4CDK9CCNT1KMT2AMEN1 | |
| SCHEMBL981807 | 0.92 | MDM4 (0.38) | KMT2AMEN1HSD17B10CD38IRAK4 | |
| SCHEMBL981954 | 0.91 | BTK (0.40) | BRD4CDK9CCNT1KMT2AMEN1 | |
| SCHEMBL982027 | 0.91 | BRD4 (0.37) | BRD4KMT2AMEN1RBP4HSD17B10 | |
| SCHEMBL981754 | 0.91 | MCHR1 (0.37) | BRD4CD38IRAK4 | |
| SCHEMBL984446 | 0.91 | BTK (0.40) | BRD4CDK9CCNT1KMT2ACASP3 | |
| SCHEMBL984600 | 0.91 | BTK (0.40) | KMT2AMEN1HTR7CD38IRAK4 | |
| SCHEMBL981788 | 0.90 | BRD4 (0.43) | BRD4KMT2AMEN1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | claimed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | BRD4 1299/4885CDK9 639/4885CCNT1 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.