Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | LIPA | P38571 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829948 | 1.00 | SRD5A2 (0.57) | SRD5A2SRD5A1ARLIPA | |
| SCHEMBL9112301 | 0.87 | SRD5A1 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL8073539 | 0.87 | SRD5A1 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL8537929 | 0.86 | SRD5A2 (0.57) | SRD5A2SRD5A1AR | |
| SCHEMBL8542751 | 0.84 | SRD5A1 (0.55) | SRD5A2SRD5A1AR | |
| SCHEMBL8542755 | 0.84 | SRD5A1 (0.55) | SRD5A2SRD5A1AR | |
| SCHEMBL8064120 | 0.83 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8080039 | 0.83 | SRD5A2 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8064128 | 0.83 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8080043 | 0.83 | SRD5A2 (0.60) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314199-B1 | 17 BETA-SUBSTITUTED-4-AZA-5 ALPHA-ANDROSTENONES AND THEIR USE AS 5 ALPHA-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1991-09-18 | — | — | EP | disclosed |
| EP-0414490-A2 | 17 Beta-acyl-4-aza-5 alpha-androst-1-ene-3-one as 5 alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1991-02-27 | — | — | EP | disclosed |
| EP-0314199-A1 | 17 Beta-substituted-4-aza-5 alpha-androstenones and their use as 5 alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1989-05-03 | — | — | EP | disclosed |
| EP-0155096-A2 | 17 Beta-Substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1985-09-18 | — | — | EP | disclosed |