Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788929 | 0.91 | MEN1 (0.60) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL3902356 | 0.88 | MEN1 (0.48) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL19317379 | 0.85 | CA12 (0.52) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL11668776 | 0.85 | MEN1 (0.54) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL12589581 | 0.84 | CA12 (0.59) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL8632462 | 0.83 | CYP1A2 (0.55) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL20937014 | 0.83 | LTA4H (0.54) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL16914705 | 0.83 | CA12 (0.50) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL23583339 | 0.82 | CYP1A2 (0.59) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL11585949 | 0.82 | KDM5A (0.53) | MEN1KMT2ACYP1A2LTA4HMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| EP-3225281-A1 | GNAQ TARGETED DSRNA COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION | Alnylam Pharmaceuticals, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-2617828-B1 | Compositions and methods for inhibiting expression of factor VII gene | ALNYLAM PHARMACEUTICALS INC (US) | 2014-09-24 | — | — | EP | disclosed |