Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230132 | 0.84 | HDAC8 (0.61) | PPARGHPGDHDAC8MMP3PLK1 | |
| SCHEMBL9831671 | 0.81 | PPARG (0.82) | PPARGHPGDHDAC8MMP3PLK1 | |
| SCHEMBL18759306 | 0.81 | KDM4E (0.52) | PPARGHPGDHDAC8HDAC3HDAC4 | |
| SCHEMBL3796366 | 0.80 | HDAC8 (0.56) | HPGDHDAC8MMP3PLK1HDAC3 | |
| SCHEMBL9829444 | 0.79 | PPARG (0.74) | PPARGHPGDHDAC8MMP3HDAC3 | |
| SCHEMBL15741895 | 0.78 | KMT2A (0.51) | HPGDHDAC8MMP3PLK1HDAC3 | |
| SCHEMBL29370451 | 0.78 | KMT2A (0.51) | HPGDHDAC8MMP3PLK1HDAC3 | |
| SCHEMBL9829615 | 0.77 | GAA (0.57) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11479124 | 0.77 | PPARG (0.60) | PPARGHPGDHDAC8HDAC3HDAC4 | |
| SCHEMBL18457431 | 0.76 | HDAC8 (0.59) | PPARGHPGDHDAC8MMP3PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |