Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828496 | 0.74 | KMT2A (0.50) | TOP2ATOP2BTDP1TSHRLMNA | |
| Hydrochloric Acid SCHEMBL9834839 | 0.70 | PKM (0.36) | PKMTOP2ATOP2BALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9835325 | 0.70 | PKM (0.36) | PKMTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL31053606 | 0.68 | PKM (0.46) | PKMTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL791534 | 0.68 | PKM (0.50) | PKMTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL14572819 | 0.64 | TSHR (0.46) | PKMTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL10987599 | 0.64 | KMT2A (0.53) | PKMALDH1A1TDP1TSHR | |
| SCHEMBL16750103 | 0.64 | TOP2A (0.50) | PKMTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL1583808 | 0.61 | CYP1A2 (0.47) | PKMALDH1A1MAPTTDP1TSHR | |
| SCHEMBL10995192 | 0.61 | KMT2A (0.64) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | claimed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | claimed |
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |