Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.47 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831414 | 0.89 | SMN1; SMN2 (0.56) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9832622 | 0.87 | POLB (0.56) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9830377 | 0.86 | POLB (0.55) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9831529 | 0.81 | POLB (0.47) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9832101 | 0.77 | POLB (0.53) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9829861 | 0.77 | L3MBTL1 (0.49) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL9830325 | 0.75 | POLB (0.45) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3434027 | 0.73 | L3MBTL1 (0.60) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL13220766 | 0.73 | NOTUM (0.64) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL189828 | 0.72 | L3MBTL1 (0.61) | POLBNOTUML3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | claimed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | claimed |
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |