Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831768 | 0.89 | KDM4E (0.64) | ALDH1A1KDM4EMAPTPOLBCCR8 | |
| SCHEMBL9831746 | 0.88 | KDM4E (0.48) | ALDH1A1KDM4EMAPTTDP1POLB | |
| SCHEMBL10408322 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAATDP1POLB | |
| SCHEMBL9829590 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTGAATDP1 | |
| SCHEMBL9830351 | 0.82 | KDM4E (0.54) | ALDH1A1KDM4EGAATDP1POLB | |
| SCHEMBL183706 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4ECCR8MEN1KMT2A | |
| SCHEMBL9830344 | 0.81 | S1PR1 (0.46) | ALDH1A1KDM4EGAAPOLBMEN1 | |
| SCHEMBL9831079 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTTDP1POLB | |
| SCHEMBL9832321 | 0.81 | ALDH1A1 (0.65) | ALDH1A1KDM4EGAATDP1POLB | |
| Hydrochloric Acid SCHEMBL183705 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KDM4ECCR8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |