Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.67 |
| ▸ | LOX | P28300 | 8/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828357 | 0.83 | CA2 (0.54) | CA2LOXLOXL2CA12CA1 | |
| Hydrochloric Acid SCHEMBL9828981 | 0.82 | CA2 (0.63) | CA2LOXLOXL2CA12CA1 | |
| SCHEMBL9829847 | 0.82 | CA2 (0.53) | CA2LOXCA12CA1 | |
| SCHEMBL9827924 | 0.81 | CA2 (0.58) | CA2LOXLOXL2CA12CA1 | |
| SCHEMBL9827904 | 0.80 | CA2 (1.00) | CA2LOXSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9828464 | 0.80 | CA2 (0.54) | CA2LOXLOXL2CA12CA1 | |
| SCHEMBL10589348 | 0.80 | CA2 (0.59) | CA2LOXLOXL2CA12CA1 | |
| Hydrochloric Acid SCHEMBL29426319 | 0.79 | CA2 (0.97) | CA2LOXSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16296148 | 0.78 | CA2 (0.61) | CA2CA12CA1CA9SLC6A2 | |
| SCHEMBL9828245 | 0.78 | CA2 (0.49) | CA2LOXLOXL2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |