Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.37 |
| ▸ | EDNRA | P25101 | 3/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10674524 | 0.90 | CYP3A4 (0.38) | CYP3A4KDM4EMAPK1 | |
| Oxalic Acid SCHEMBL9829862 | 0.82 | TP53 (0.41) | POLBMAPTCYP1A2CYP2D6RAB9A | |
| Oxalic Acid SCHEMBL9831243 | 0.80 | SMPD1 (0.47) | CYP3A4MAPTCYP1A2CYP2D6ALDH1A1 | |
| Oxalic Acid SCHEMBL9831824 | 0.78 | SMPD1 (0.46) | MAPTALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL10672287 | 0.77 | CYP3A4 (0.53) | CYP3A4POLBMAPTRAB9ASLC6A9 | |
| Fumaric Acid SCHEMBL10672281 | 0.77 | CYP3A4 (0.53) | CYP3A4POLBMAPTRAB9ASLC6A9 | |
| SCHEMBL9829954 | 0.77 | CYP3A4 (0.55) | CYP3A4POLBMAPTCYP1A2CYP2D6 | |
| Fumaric Acid SCHEMBL10672976 | 0.77 | CYP3A4 (0.51) | CYP3A4POLBMAPTRAB9ASLC6A9 | |
| Fumaric Acid SCHEMBL10672966 | 0.77 | CYP3A4 (0.51) | CYP3A4POLBMAPTRAB9ASLC6A9 | |
| SCHEMBL9828381 | 0.76 | CYP3A4 (0.53) | CYP3A4POLBMAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233291-B1 | 2-ARYLBENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1991-03-13 | — | — | EP | disclosed |
| US-4739050-A | CALCIUM ANTAGONIST, ANTICOAGULANT | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| EP-0233291-A1 | 2-ARYLBENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1987-08-26 | — | — | EP | disclosed |