Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10669220 | 0.88 | KDM4E (0.48) | TP53KDM4EMAPK1RAB9ASMPD1 | |
| Oxalic Acid SCHEMBL9831243 | 0.87 | SMPD1 (0.47) | KDM4ESMPD1CYP1A2CYP2D6ALDH1A1 | |
| Oxalic Acid SCHEMBL10672405 | 0.86 | KDM4E (0.48) | TP53KDM4EMAPK1RAB9AMEN1 | |
| Oxalic Acid SCHEMBL9831824 | 0.85 | SMPD1 (0.46) | KDM4ESMPD1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9829535 | 0.84 | RAB9A (0.41) | TP53RAB9ASMPD1MEN1KMT2A | |
| SCHEMBL9829359 | 0.83 | RAB9A (0.41) | TP53RAB9ASMPD1MEN1KMT2A | |
| Oxalic Acid SCHEMBL9831357 | 0.82 | CYP3A4 (0.47) | KDM4EMAPK1RAB9AKMT2ASCN9A | |
| Oxalic Acid SCHEMBL10674524 | 0.80 | CYP3A4 (0.38) | TP53KDM4EMAPK1SMPD1DRD2 | |
| SCHEMBL9829983 | 0.80 | CYP1A2 (0.40) | TP53KDM4EMAPK1RAB9ASMPD1 | |
| SCHEMBL9828930 | 0.80 | RAB9A (0.41) | TP53RAB9ASMPD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233291-B1 | 2-ARYLBENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1991-03-13 | — | — | EP | disclosed |
| US-4739050-A | CALCIUM ANTAGONIST, ANTICOAGULANT | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| EP-0233291-A1 | 2-ARYLBENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1987-08-26 | — | — | EP | disclosed |