Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 12/20 | 0.57 |
| ▸ | METAP2 | P50579 | 8/20 | 0.57 |
| ▸ | METAP1 | P53582 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | PKM | P14618 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833638 | 0.79 | PDE4A (0.66) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| Water SCHEMBL10470921 | 0.78 | PDE4A (0.65) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL9833271 | 0.78 | MAPT (0.57) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL13866537 | 0.76 | NPC1 (0.81) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL9833589 | 0.75 | CBFB (0.56) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL30692551 | 0.74 | CBFB (1.00) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL9834932 | 0.74 | MAPT (0.40) | NPC1RAB9APKMSMN1; SMN2KDM4E | |
| SCHEMBL125187 | 0.74 | CBFB (1.00) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL9385715 | 0.74 | CBFB (0.54) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10534267 | 0.74 | CBFB (0.54) | CBFBMETAP2METAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |