Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829826 | 0.92 | RAB9A (0.49) | RAB9ANPC1POLBALDH1A1TLR7 | |
| SCHEMBL9830487 | 0.91 | RAB9A (0.48) | RAB9ANPC1POLBALDH1A1TLR7 | |
| Monoethanolamine SCHEMBL9830948 | 0.89 | CDC25A (0.44) | RAB9ANPC1POLBALDH1A1TLR7 | |
| SCHEMBL9829838 | 0.82 | RAB9A (0.49) | RAB9ANPC1ALDH1A1TLR7CDK5 | |
| SCHEMBL9830880 | 0.81 | CDK5 (0.52) | RAB9ANPC1ALDH1A1TLR7CDK5 | |
| SCHEMBL9830585 | 0.81 | RAB9A (0.40) | RAB9ANPC1POLBALDH1A1TLR7 | |
| SCHEMBL9831158 | 0.81 | CDC25A (0.49) | RAB9ANPC1POLBALDH1A1TLR7 | |
| SCHEMBL9830549 | 0.81 | TP53 (0.45) | RAB9ANPC1POLBALDH1A1CDK5 | |
| Monoethanolamine SCHEMBL10553577 | 0.80 | RAB9A (0.53) | RAB9ANPC1POLBALDH1A1TLR7 | |
| SCHEMBL9832511 | 0.80 | CDK5 (0.55) | RAB9ANPC1POLBALDH1A1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321115-B1 | CARBOXAMIDE DERIVATIVES HAVING TETRAZOLE AND THIAZOLE RINGS AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4946855-A | ANTIALLERGIC | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0321115-A1 | Carboxamide derivatives having tetrazole and thiazole rings and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-21 | — | — | EP | disclosed |