Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | LOX | P28300 | 3/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828663 | 0.81 | CA2 (0.63) | CA2CA12CA9CA1GAA | |
| SCHEMBL9235944 | 0.81 | LOX (0.61) | CA2CA12CA9CA1CA7 | |
| SCHEMBL9139919 | 0.81 | CA2 (0.49) | CA2CA12CA9CA1GAA | |
| SCHEMBL10589348 | 0.81 | CA2 (0.59) | CA2CA12CA9CA1CA7 | |
| SCHEMBL9827924 | 0.79 | CA2 (0.58) | CA2CA12CA9CA1CA7 | |
| SCHEMBL9139390 | 0.78 | CA2 (0.46) | CA2CA12CA9CA1GAA | |
| SCHEMBL19274520 | 0.77 | LOX (0.73) | LOXLOXL2 | |
| SCHEMBL9830538 | 0.77 | CA2 (0.49) | CA2CA12CA9CA1CA7 | |
| SCHEMBL29724901 | 0.77 | GAA (0.67) | CA2CA12CA9CA1GAA | |
| SCHEMBL18838 | 0.77 | GAA (0.67) | CA2CA12CA9CA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4542152-A | GLAUCOMA | MERCK & CO., INC. (US) | 1985-09-17 | — | — | US | claimed |
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0130109-B1 | DERIVATIVES OF THIOPHENESULFONAMIDE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |
| US-4585787-A | GLAUCOMA | MERCK & CO., INC. (US) | 1986-04-29 | — | — | US | disclosed |
| US-4542152-A | GLAUCOMA | MERCK & CO., INC. (US) | 1985-09-17 | — | — | US | disclosed |
| EP-0130109-A2 | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| US-4477466-A | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1984-10-16 | — | — | US | disclosed |