Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517751 | 0.85 | SMN1; SMN2 (0.40) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL30667436 | 0.85 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL2093788 | 0.82 | SMN1; SMN2 (0.38) | RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL22279589 | 0.80 | SMN1; SMN2 (0.34) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL18876504 | 0.79 | MAPK1 (0.40) | SMN1; SMN2NPC1ALDH1A1GAAHTT | |
| SCHEMBL18876467 | 0.79 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL16250650 | 0.79 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL238377 | 0.79 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL14922241 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL8275459 | 0.79 | MAPT (0.46) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |