Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830476 | 0.90 | HTT (0.45) | KDM4ETSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9830192 | 0.83 | MAPT (0.54) | KDM4ETSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9830654 | 0.83 | ALDH1A1 (0.41) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL9832124 | 0.81 | MAPT (0.41) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL9829579 | 0.81 | ALDH1A1 (0.46) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL9832074 | 0.81 | KMT2A (0.38) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL9830331 | 0.81 | ALDH1A1 (0.46) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL10408449 | 0.81 | ALDH1A1 (0.43) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL9832857 | 0.81 | ALDH1A1 (0.53) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL9830727 | 0.81 | KMT2A (0.42) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |