Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL139176 | 0.91 | SMN1; SMN2 (0.57) | SMN1; SMN2NLRP3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9831653 | 0.88 | NLRP3 (0.61) | SMN1; SMN2NLRP3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4824607 | 0.85 | MAPT (0.45) | SMN1; SMN2NLRP3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29264328 | 0.85 | MAPT (0.47) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9830404 | 0.81 | MAPT (0.56) | SMN1; SMN2NLRP3ALDH1A1HTTMAPT | |
| SCHEMBL15483670 | 0.81 | MAPT (0.48) | SMN1; SMN2NLRP3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6253809 | 0.81 | MAPT (0.72) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6954918 | 0.81 | MAPT (0.69) | SMN1; SMN2CYP1A2CYP2C9ALDH1A1KMT2A | |
| SCHEMBL9829734 | 0.80 | NLRP3 (0.56) | SMN1; SMN2NLRP3ALDH1A1LMNATOP2A | |
| SCHEMBL20836515 | 0.79 | MAPT (0.50) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |