Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 10/20 | 0.76 |
| ▸ | HRH1 | P35367 | 8/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | FNTA | P49354 | 4/20 | 0.56 |
| ▸ | FNTB | P49356 | 4/20 | 0.56 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879488 | 0.86 | PTAFR (1.00) | PTAFRHRH1CHRM2HTR2AOPRK1 | |
| SCHEMBL14007275 | 0.85 | PTAFR (0.76) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| SCHEMBL29626502 | 0.85 | HRH1 (0.82) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| SCHEMBL31384618 | 0.85 | HRH1 (0.82) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| SCHEMBL4460572 | 0.85 | HRH1 (0.82) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| Azatadine SCHEMBL29746602 | 0.84 | HRH1 (1.00) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| Azatadine SCHEMBL3721 | 0.84 | HRH1 (1.00) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| Azatadine SCHEMBL29363595 | 0.84 | HRH1 (1.00) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| SCHEMBL2624623 | 0.84 | HRH1 (0.73) | PTAFRHRH1CHRM2HTR1ACHRM1 | |
| SCHEMBL14198336 | 0.83 | HRH1 (0.56) | PTAFRHRH1CHRM2HTR1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208855-B1 | PROCESS FOR PREPARING PIPERIDYLIDENE DIHYDRODIBENZO(A,D)CYCLOHEPTENES AND AZA DERIVATIVES THEREOF, COMPOUNDS OBTAINED BY SUCH PROCESS AND THE USE OF SUCH COMPOUNDS FOR PREPARING USEFUL PHARMACEUTICAL COMPOSITIONS | SCHERING CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4873335-A | 3-phenethyl-2-benzene-amides or aza-derivatives thereof | SCHERING CORPORATION (US) | 1989-10-10 | — | — | US | disclosed |
| US-4731447-A | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof | SCHERING CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
| US-4659716-A | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines | SCHERING CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0208855-A1 | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions | SCHERING CORPORATION (US) | 1987-01-21 | — | — | EP | disclosed |