SCHEMBL9832217

SCHEMBL9832217

COc1ccc(CCN(C)CC[C@@]2(O)CCc3cc(OC)c(OC)cc3[C@@H]2C(C)C)cc1OC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.52
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 2/20 0.52
BLM P54132 1/20 0.51
PMP22 Q01453 1/20 0.51
SMPD1 P17405 4/20 0.44
ABCB1 P08183 5/20 0.43
SCN1A P35498 2/20 0.42
SCN2A Q99250 2/20 0.42
SCN3A Q9NY46 2/20 0.42
MAPT P10636 1/20 0.42
HCN4 Q9Y3Q4 1/20 0.42
AOC3 Q16853 1/20 0.42
KDM4E B2RXH2 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALOX15 P16050 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2C19 P33261 2/20 0.41
ABCC1 P33527 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9827555 0.94 CYP3A4 (0.50) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9829660 0.93 CYP3A4 (0.46) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL9827829 0.93 CYP3A4 (0.47) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9829663 0.93 CYP3A4 (0.46) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL10794825 0.93 CYP3A4 (0.47) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL9827448 0.92 CYP3A4 (0.45) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL10792651 0.92 CYP3A4 (0.45) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9827613 0.92 CYP3A4 (0.44) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9828675 0.91 CYP3A4 (0.42) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9736708 0.90 CYP3A4 (0.56) CYP3A4CYP1A2CYP2D6BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0177960-B1 DERIVATIVES OF TETRAHYDRONAPHTHALENE, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM HOFFMANN LA ROCHE (CH) 1991-03-20 EP disclosed
US-4680310-A HYPOTENSIVE AGENTS HOFFMANN-LA ROCHE INC. (US) 1987-07-14 US disclosed
EP-0177960-A2 Derivatives of tetrahydronaphthalene, process and intermediates for their preparation and medicines containing them F. HOFFMANN-LA ROCHE AG (CH) 1986-04-16 EP disclosed