Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834234 | 0.99 | PGR (0.41) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9831415 | 0.96 | PGR (0.42) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL10471038 | 0.95 | PGR (0.41) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9831005 | 0.89 | MAPT (0.51) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9830360 | 0.87 | MAPT (0.52) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9833237 | 0.85 | MAPT (0.51) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9832386 | 0.83 | MAPT (0.52) | PGRMAPK14KMT2APOLBMEN1 | |
| SCHEMBL9832850 | 0.83 | POLB (0.43) | KMT2APOLBMEN1HCAR3NPC1 | |
| SCHEMBL9834325 | 0.81 | POLB (0.41) | KMT2APOLBMEN1HCAR3NPC1 | |
| SCHEMBL9831423 | 0.81 | MAPT (0.40) | KMT2APOLBMEN1HCAR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |