Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829332 | 0.90 | GAA (0.57) | GAATOP2ATHRBPOLBKMT2A | |
| SCHEMBL9831248 | 0.89 | GAA (0.48) | GAATOP2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19974750 | 0.87 | CHRM2 (0.57) | CHRM2SMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL31083326 | 0.86 | GAA (0.57) | GAANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8135574 | 0.86 | GAA (0.57) | GAANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9830404 | 0.84 | MAPT (0.56) | GAATOP2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9830719 | 0.83 | ALDH1A1 (0.54) | GAANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL3213693 | 0.83 | ALDH1A1 (0.58) | GAACHRM2SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL12851808 | 0.83 | CHRM2 (0.55) | CHRM2NPSR1ALDH1A1POLBKMT2A | |
| SCHEMBL30063371 | 0.83 | ALDH1A1 (0.58) | GAACHRM2SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101058558-A | 4-Oxy-1(4H)-quinoline carboxylic acids compound and composition with aldose reductase inhibition activity and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2007-10-24 | — | — | CN | claimed |
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| CN-101058558-A | 4-Oxy-1(4H)-quinoline carboxylic acids compound and composition with aldose reductase inhibition activity and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2007-10-24 | — | — | CN | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |