Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5907087 | 1.00 | USP2 (0.33) | USP2CYP3A4SMN1; SMN2THRBTSHR | |
| SCHEMBL27076632 | 0.92 | SMN1; SMN2 (0.36) | USP2CYP3A4SMN1; SMN2THRBTSHR | |
| SCHEMBL5760929 | 0.90 | USP2 (0.39) | USP2CYP3A4SMN1; SMN2TSHRPTPN1 | |
| SCHEMBL2948491 | 0.90 | USP2 (0.39) | USP2CYP3A4SMN1; SMN2TSHRPTPN1 | |
| SCHEMBL15484241 | 0.84 | TDP1 (0.38) | USP2CYP3A4SMN1; SMN2THRBTSHR | |
| SCHEMBL6419715 | 0.83 | — | — | |
| SCHEMBL7846832 | 0.83 | LMNA (0.33) | PTPN1ALDH1A1 | |
| SCHEMBL8722064 | 0.82 | TSHR (0.43) | TSHRPSMD14PLA2G1BMMP2ATG4B | |
| SCHEMBL9064876 | 0.82 | PTPN1 (0.33) | USP2CYP3A4SMN1; SMN2THRBPTPN1 | |
| 1,6-Hexanediol SCHEMBL8319566 | 0.81 | TSHR (0.41) | SMN1; SMN2TSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | claimed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | claimed |