Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19834411 | 0.83 | NPC1 (0.49) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 | |
| SCHEMBL24784588 | 0.81 | HDAC1 (0.55) | ALDH1A1KDM4EHPGDNOTUMHDAC3 | |
| SCHEMBL29379125 | 0.81 | NOTUM (0.46) | ALDH1A1KDM4ENOTUMHDAC3HDAC4 | |
| SCHEMBL23923001 | 0.81 | NOTUM (0.46) | ALDH1A1KDM4ENOTUMHDAC3HDAC4 | |
| SCHEMBL31590031 | 0.79 | NOTUM (0.38) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 | |
| SCHEMBL29183375 | 0.78 | KDM4E (0.53) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 | |
| Alcohol SCHEMBL27863341 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 | |
| SCHEMBL19043355 | 0.76 | KDM4E (0.47) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 | |
| SCHEMBL22042181 | 0.74 | HDAC3 (0.62) | KDM4ENOTUMHDAC3HDAC4HDAC1 | |
| SCHEMBL10745283 | 0.74 | KDM4E (0.52) | ALDH1A1KDM4EHPGDNOTUMMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220573-B1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4774253-A | ETHER,-ACIDS, ESTERS OR AMIDES | HOFFMANN-LA ROCHE INC. (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0220573-A1 | Heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1987-05-06 | — | — | EP | disclosed |