Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697969 | 0.83 | NPC1 (0.49) | NPC1RAB9ANOTUMPIK3CDCYP2A6 | |
| SCHEMBL9832665 | 0.83 | ALDH1A1 (0.53) | NPC1RAB9ANOTUMHDAC1HDAC2 | |
| SCHEMBL23923001 | 0.79 | NOTUM (0.46) | NPC1RAB9ANOTUMHDAC1HDAC2 | |
| SCHEMBL29379125 | 0.79 | NOTUM (0.46) | NPC1RAB9ANOTUMHDAC1HDAC2 | |
| SCHEMBL19834349 | 0.77 | NOTUM (0.43) | NPC1RAB9ANOTUMHDAC1HDAC2 | |
| SCHEMBL24784588 | 0.75 | HDAC1 (0.55) | NPC1RAB9ANOTUMCYP2A6HDAC1 | |
| SCHEMBL31590031 | 0.70 | NOTUM (0.38) | NOTUMKDM4EALDH1A1HPGDCASP3 | |
| SCHEMBL2438690 | 0.70 | NPC1 (0.55) | NPC1RAB9ANOTUMCYP2A6HDAC1 | |
| SCHEMBL4881364 | 0.70 | ALOX15 (0.71) | NPC1RAB9ANOTUMCYP2A6HDAC4 | |
| SCHEMBL19834409 | 0.70 | NPC1 (0.49) | NPC1RAB9ANOTUMPIK3CDCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10252997-B2 | Monocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-04-09 | — | — | US | disclosed |
| US-20180079723-A1 | MONOCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-22 | — | — | US | disclosed |
| EP-3279183-A1 | MONOCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10252997-B2 | Monocyclic compound | FABP1, CPT1A, GOT2 | NPC1 112/4885RAB9A 3714/4885NOTUM 284/4885 |
| US-20180079723-A1 | MONOCYCLIC COMPOUND | FABP1, CPT1A, GOT2 | NPC1 112/4885RAB9A 3714/4885NOTUM 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.