Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833427 | 0.84 | TDP1 (0.39) | MAPTPOLBALDH1A1HPGDLMNA | |
| SCHEMBL9833004 | 0.84 | CYP1A2 (0.39) | MAPTPOLBALDH1A1HPGDLMNA | |
| SCHEMBL9832441 | 0.84 | MAPT (0.41) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL9833981 | 0.82 | MAPK14 (0.33) | KDM4EMAPTALDH1A1MAPK14SMN1; SMN2 | |
| SCHEMBL9834492 | 0.78 | KDM4E (0.34) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL9835008 | 0.78 | KDM4E (0.34) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL31730384 | 0.77 | PIM1 (0.46) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL31730669 | 0.77 | PIM1 (0.46) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL12713566 | 0.77 | PIM1 (0.46) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL23578378 | 0.76 | MEN1 (0.37) | KDM4EMAPTPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| CN-85103724-B | Process for preparing pyrrolobenzimidazoles | 曼海姆伯灵格股份公司 | 1988-07-06 | — | — | CN | disclosed |
| CN-85103724-A | The method for preparing novel pyrrolo-benzoglyoxaline | — | 1986-07-02 | — | — | CN | disclosed |