Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SOD1 | P00441 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834492 | 0.89 | KDM4E (0.34) | KDM4EPOLBMAPTKMT2AALDH1A1 | |
| SCHEMBL9833652 | 0.85 | ALDH1A1 (0.36) | KDM4EPOLBMAPTKMT2AALDH1A1 | |
| SCHEMBL9835813 | 0.84 | ATAD2 (0.31) | — | |
| SCHEMBL9832551 | 0.83 | KDM4E (0.39) | KDM4EPOLBMAPTKMT2AALDH1A1 | |
| SCHEMBL9836473 | 0.82 | MAPK14 (0.33) | — | |
| SCHEMBL9833082 | 0.82 | KDM4E (0.33) | KDM4EALDH1A1 | |
| SCHEMBL9832724 | 0.78 | KDM4E (0.36) | KDM4EPOLBMAPTALDH1A1HPGD | |
| SCHEMBL9832844 | 0.76 | KDM4E (0.40) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL9834972 | 0.75 | ATAD2 (0.50) | — | |
| SCHEMBL31730669 | 0.74 | PIM1 (0.46) | KDM4EPOLBMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |