Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830967 | 0.83 | SRD5A1 (0.49) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9830224 | 0.81 | MAPT (0.55) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9831758 | 0.80 | KDM4E (0.42) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9832359 | 0.80 | BAZ2B (0.47) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9830197 | 0.79 | MAPT (0.41) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9829654 | 0.79 | KMT2A (0.45) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9832169 | 0.77 | PDE3B (0.40) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9832862 | 0.77 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTKDM4ERARA | |
| SCHEMBL9832079 | 0.77 | PDE3B (0.40) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL9829790 | 0.77 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |