Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833648 | 0.82 | AURKA (0.37) | POLBALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9835221 | 0.82 | KDM4E (0.37) | KMT2APOLBALDH1A1TP53CYP3A4 | |
| SCHEMBL9835776 | 0.80 | FABP6 (0.40) | KMT2AALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9833681 | 0.80 | AURKA (0.35) | KMT2APOLBALDH1A1TP53CYP1A2 | |
| SCHEMBL9834977 | 0.78 | KDM4E (0.38) | KMT2AALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9832983 | 0.78 | ALDH1A1 (0.38) | POLBALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9834509 | 0.78 | KMT2A (0.42) | KMT2APOLBALDH1A1TP53CYP1A2 | |
| SCHEMBL9834064 | 0.78 | KDM4E (0.43) | POLBALDH1A1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL10557338 | 0.77 | MAPT (0.36) | POLBALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9833417 | 0.77 | HSD17B10 (0.34) | ALDH1A1TP53CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |