Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150222 | 0.75 | MAPT (0.42) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL31010750 | 0.74 | AHR (0.59) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| Water SCHEMBL10473604 | 0.73 | MAPT (0.41) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL4150642 | 0.68 | MAPT (0.42) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL2705071 | 0.68 | — | — | |
| SCHEMBL23788017 | 0.67 | AHR (0.61) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL9834236 | 0.67 | AURKA (0.51) | PDE3BPDE3APDK2PGRPDE4A | |
| SCHEMBL5441646 | 0.66 | AHR (0.60) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL1436084 | 0.66 | GRIA1 (0.53) | AHRPDE3BPDE3ACMA1EIF2AK2 | |
| SCHEMBL9298074 | 0.66 | AHR (0.50) | AHRPDE3BPDE3ACMA1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257334-B1 | TRICYCLIC BENZOTRIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1991-01-02 | — | — | EP | disclosed |
| US-4835167-A | Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0257334-A2 | Tricyclic benzotriazoles, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |