Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 9/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MPC2 | O95563 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832774 | 0.88 | ALDH1A1 (0.45) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9565667 | 0.87 | MAPT (0.53) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9831543 | 0.87 | MAPT (0.58) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9468083 | 0.86 | ALDH1A1 (0.44) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9832462 | 0.86 | PTPN1 (0.46) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9829846 | 0.86 | PPARG (0.49) | ALDH1A1NPSR1PTPN1PPARGPOLB | |
| SCHEMBL9831532 | 0.85 | ALDH1A1 (0.43) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9833176 | 0.83 | POLB (0.47) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL9832231 | 0.83 | MAPT (0.45) | ALDH1A1NPSR1MAOACISD1MAPT | |
| SCHEMBL377496 | 0.83 | FFAR1 (0.43) | ALDH1A1NPSR1MAOACISD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283035-B1 | BENZOXAZOLE DERIVATIVES AND PREPARATION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1991-11-06 | — | — | EP | disclosed |
| US-4948900-A | INTERMEDIATES FOR DIABETES THERAPEUTIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |
| US-4897393-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0283035-A1 | Benzoxazole derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |