Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690377 | 0.85 | PDE5A (0.67) | PDE5ANOTUMAADATALDH1A1KDM4E | |
| SCHEMBL10506330 | 0.82 | PDE5A (0.44) | PDE5ANOTUMALDH1A1KDM4EMEN1 | |
| SCHEMBL11116301 | 0.81 | NOTUM (0.54) | PDE5ANOTUMAADATALDH1A1KDM4E | |
| SCHEMBL9834775 | 0.81 | PDE5A (0.48) | PDE5ANOTUMALDH1A1KDM4EMEN1 | |
| SCHEMBL7895806 | 0.81 | PDE5A (0.43) | PDE5ANOTUMAADATALDH1A1KDM4E | |
| SCHEMBL11006323 | 0.81 | PDE5A (0.43) | PDE5ANOTUMALDH1A1KDM4EMEN1 | |
| SCHEMBL9834316 | 0.80 | HSD17B10 (0.53) | PDE5ANOTUMAADATALDH1A1KDM4E | |
| SCHEMBL2471204 | 0.79 | PDE5A (0.52) | PDE5ANOTUMALDH1A1KDM4EMEN1 | |
| SCHEMBL10731905 | 0.79 | PDE5A (0.59) | PDE5ANOTUMAADATALDH1A1KDM4E | |
| SCHEMBL28350878 | 0.79 | PDE5A (1.00) | PDE5ANOTUMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |