Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038026 | 0.88 | NPC1 (0.47) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9831677 | 0.87 | KDM4E (0.54) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9833439 | 0.86 | KDM4E (0.50) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9833589 | 0.78 | CBFB (0.56) | MAPTKDM4EHPGDRAB9ANPC1 | |
| SCHEMBL9831222 | 0.78 | MAPT (0.54) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL11023775 | 0.77 | NPC1 (0.45) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9833850 | 0.76 | ALDH1A1 (0.53) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9833271 | 0.76 | MAPT (0.57) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9831369 | 0.75 | MAPT (0.51) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL10534186 | 0.75 | MAPT (0.53) | MAPTKDM4EHPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |