Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835620 | 0.93 | NPC1 (0.46) | NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL9833430 | 0.80 | DHFR (0.42) | NPC1 | |
| SCHEMBL9833971 | 0.78 | — | — | |
| SCHEMBL9833493 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL10698643 | 0.76 | DHFR (0.42) | — | |
| SCHEMBL9833630 | 0.76 | — | — | |
| SCHEMBL9451944 | 0.75 | — | — | |
| SCHEMBL9835839 | 0.72 | — | — | |
| SCHEMBL9835802 | 0.72 | ABL1 (0.45) | — | |
| SCHEMBL9451955 | 0.70 | CHRM2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234011-B1 | 4-(1,2,5,6-TETRAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES AND 4-(HEXAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | claimed |
| EP-0234011-A1 | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines | WARNER-LAMBERT COMPANY (US) | 1987-09-02 | — | — | EP | claimed |
| EP-0234011-B1 | 4-(1,2,5,6-TETRAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES AND 4-(HEXAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |
| US-4739067-A | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS, HYPOTENSIVE AGENT, HORMONE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0234011-A1 | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines | WARNER-LAMBERT COMPANY (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4650805-A | 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity | WARNER-LAMBERT COMPANY (US) | 1987-03-17 | — | — | US | disclosed |