SCHEMBL9834697

SCHEMBL9834697

O=C1OC(c2ccc(Cl)cc2Cl)C(Cn2cncn2)(c2ccc(Cl)cc2)O1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.43
THRB P10828 2/20 0.43
CYP2C9 P11712 3/20 0.42
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C19 P33261 2/20 0.38
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
LMNA P02545 2/20 0.35
PKM P14618 1/20 0.35
TSHR P16473 2/20 0.35
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35
SLC6A3 Q01959 2/20 0.35
NR1I2 O75469 1/20 0.35
FYN P06241 1/20 0.35
PGR P06401 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10845394 0.88 CYP3A4 (0.43) CYP3A4THRBCYP2C9KDM4ECYP1A2
Alteconazole SCHEMBL30416434 0.87 CYP3A4 (0.49) CYP3A4THRBCYP2C9KDM4ECYP1A2
Alteconazole SCHEMBL9748291 0.87 CYP3A4 (0.49) CYP3A4THRBCYP2C9KDM4ECYP1A2
Alteconazole SCHEMBL2110163 0.87 CYP3A4 (0.49) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL9833161 0.82 CYP3A4 (0.50) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL10843665 0.80 CYP3A4 (0.48) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL10844736 0.80 CYP3A4 (0.46) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL10425812 0.78 CYP3A4 (0.43) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL3467654 0.77 CYP3A4 (0.48) CYP3A4THRBCYP2C9KDM4ECYP1A2
SCHEMBL2557411 0.77 CYP3A4 (0.48) CYP3A4THRBCYP2C9KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0133248-B1 1,2,4-TRIAZOL-1-YL-DERIVATIVES SHIONOGI & CO., LTD. (JP) 1991-11-21 EP claimed
US-4612322-A FUNGICIDES SHIONOGI & CO., LTD. (JP) 1986-09-16 US claimed
EP-0133248-A2 1,2,4-Triazol-1-yl-derivatives SHIONOGI & CO., LTD. (JP) 1985-02-20 EP claimed