Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | RABGGTB | P53611 | 1/20 | 0.30 |
| ▸ | RABGGTA | Q92696 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293841 | 1.00 | MEN1 (0.32) | MEN1KMT2AKDM4EPKMBACE1 | |
| SCHEMBL7293845 | 1.00 | MEN1 (0.32) | MEN1KMT2AKDM4EPKMBACE1 | |
| SCHEMBL7293850 | 1.00 | MEN1 (0.32) | MEN1KMT2AKDM4EPKMBACE1 | |
| SCHEMBL10528950 | 0.84 | SPHK1 (0.35) | MEN1KMT2ABACE1CTSDRABGGTB | |
| SCHEMBL10591597 | 0.84 | BACE1 (0.31) | BACE1CTSD | |
| SCHEMBL10591602 | 0.84 | BACE1 (0.31) | BACE1CTSD | |
| SCHEMBL10591603 | 0.84 | BACE1 (0.31) | BACE1CTSD | |
| SCHEMBL7293176 | 0.83 | ACHE (0.32) | BACE1CTSD | |
| SCHEMBL7293173 | 0.83 | ACHE (0.32) | BACE1CTSD | |
| SCHEMBL7293170 | 0.83 | ACHE (0.32) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |