Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836486 | 0.84 | HTT (0.37) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9834526 | 0.81 | HTT (0.36) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9836183 | 0.80 | HTT (0.35) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9833927 | 0.80 | HCRTR1 (0.44) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9837203 | 0.77 | RXFP1 (0.38) | KMT2AMEN1HTTARRXFP1 | |
| SCHEMBL9833878 | 0.77 | CASP3 (0.38) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL10731348 | 0.73 | RXFP1 (0.38) | KMT2AMEN1HTTARRXFP1 | |
| SCHEMBL10730941 | 0.69 | HTT (0.37) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9834075 | 0.69 | RXFP1 (0.39) | CASP3KMT2AMEN1HTTAR | |
| SCHEMBL9835091 | 0.69 | HTT (0.35) | CASP3KMT2AMEN1HTTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175263-B1 | 2-AMINO-3-CHLOROMETHYL-5-(DICHLOROMETHYL)-PYRAZINES AND PROCESS FOR THEIR PREPARATION | BASF Aktiengesellschaft (DE) | 1991-06-05 | — | — | EP | disclosed |
| US-4692527-A | 2-amino-3,5-di-(halomethyl)-pyrazines and their preparation | BASF AKTIENGESELLSCHAFT (DE) | 1987-09-08 | — | — | US | disclosed |
| EP-0175263-A2 | 2-Amino-3-chloromethyl-5-(dichloromethyl)-pyrazines and process for their preparation | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |