Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | PDE4A | P27815 | 9/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584926 | 0.86 | MAPK1 (1.00) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5964701 | 0.86 | PDE4A (0.73) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12013393 | 0.84 | MAPK1 (0.56) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6662589 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL6244272 | 0.79 | PDE4A (0.68) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6664629 | 0.78 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL6665761 | 0.78 | PDE4A (0.74) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3612101 | 0.78 | ADORA2B (0.69) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7604842 | 0.77 | PDE4A (0.65) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6660919 | 0.77 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454773-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | Bundgaard, Hans (DK) | 1991-11-06 | — | — | EP | claimed |
| WO-1990008128-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | BUNDGAARD HANS (DK) | 1990-07-26 | — | — | WO | claimed |