Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836107 | 0.80 | CYP1A2 (0.45) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL7679044 | 0.75 | SMYD3 (0.53) | CMA1ALDH1A1AHRATMTDP1 | |
| SCHEMBL9836593 | 0.72 | CRBN (0.46) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3255662 | 0.72 | SMYD3 (0.53) | ALDH1A1AHRATMTDP1L3MBTL1 | |
| SCHEMBL10893926 | 0.69 | TTR (0.59) | ALDH1A1ATMTDP1L3MBTL1CNR2 | |
| SCHEMBL496039 | 0.68 | AHR (0.44) | RIPK1CMA1CCNB2CDK1CCNB1 | |
| SCHEMBL10130338 | 0.68 | AHR (0.44) | RIPK1CMA1CCNB2CDK1CCNB1 | |
| SCHEMBL624585 | 0.68 | CCNB2 (0.54) | CMA1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL29622057 | 0.68 | CCNB2 (0.54) | CMA1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL27620600 | 0.68 | ALDH1A1 (0.56) | ALDH1A1ATMTDP1L3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |