SCHEMBL9835677

SCHEMBL9835677

O=C(Cl)Nc1cc(Cl)cc(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
MAPT P10636 3/20 0.55
NPSR1 Q6W5P4 2/20 0.55
RAB9A P51151 1/20 0.55
P2RY1 P47900 1/20 0.52
POLB P06746 1/20 0.52
ACP1 P24666 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.48
P2RX1 P51575 1/20 0.48
P2RX4 Q99571 1/20 0.48
P2RX7 Q99572 1/20 0.48
TMPRSS4 Q9NRS4 1/20 0.48
FABP4 P15090 1/20 0.48
IDO1 P14902 1/20 0.48
GRM4 Q14833 2/20 0.47
FADS1 O60427 1/20 0.47
EGFR P00533 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20560630 0.85 GRM4 (0.53) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL11155152 0.84 S1PR2 (0.42) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL15786287 0.82 MEN1 (0.76) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL2090730 0.80 MEN1 (0.55) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL711831 0.80 MEN1 (0.61) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL3890955 0.78 MEN1 (0.53) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL2728856 0.78 LMNA (0.58) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL351911 0.78 MEN1 (0.53) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL2891974 0.78 NPC1 (0.61) MEN1KMT2AMAPTNPSR1RAB9A
SCHEMBL11066912 0.78 MEN1 (0.74) MEN1KMT2AMAPTNPSR1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed